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<span class=" fc-2nd">Jul 16, 2018 · </span> Bottom Line – Kaopectate vs Imodium. Kaopectate is an antacid and anti-diarrhea medication which is used to treat nausea, heartburn, indigestion, diarrhea, and upset stomach. Imodium is a medication that slows the rhythm of digestion. This alow the...